Association of NOD1 (CARD4) insertion/deletion polymorphism with susceptibility to IBD: A meta-analysis

Table 1 Characteristics of the studies included in the meta-analysis

ID	Study	Yr	Ethnic group	Diseases	Sample size (frequency of GG allele, %)		OR (95%CI) for GG vs T allele	Hardy-Weinberg equilibrium of genotype control
					Case	Control
1	Hancock et al[19]	2008	Caucasian	CD	594 (27.1)	1024 (24.6)	1.130 (0.960-1.330)	0.010
2	Cantó et al[20]	2007	Caucasian	CD	97 (21.7)	50 (31.0)	0.615 (0.357-1.060)	0.147
3	Henckaerts et al[21]	2007	Caucasian	IBD	1052 (24.5)	280 (25.4)	0.952 (0.768-1.180)	0.751
				CD	809 (24.8)		0.973 (0.780-1.214)
				UC	222 (22.9)		0.878 (0.656-1.175)
4	Van Limbergen et al[22]	2007	Caucasian (Scottish)	IBD	1079 (26.1)	1233 (26.4)	0.984 (0.863-1.089)	0.261
				CD	515 (26.4)		1.003 (0.850-1.182)
				UC	537 (26.0)		0.985 (0.837-1.160)
5	Van Limbergen et al[22]	2007	Caucasian (Swedish)	IBD	632 (25.3)	277 (23.3)	1.112 (0.880-1.406)	0.741
				CD	244 (24.7)		1.086 (0.817-1.444)
				UC	388 (25.5)		1.129 (0.875-1.456)
6	Franke et al[23]	2006	Caucasian	IBD	961 (22.4)	841 (21.5)	1.055 (0.900-1.235)	0.958
				CD	633 (21.1)		0.983 (0.822-1.174)
				UC	332 (24.4)		1.181 (0.955-1.460)
7	Tremelling et al[24]	2006	Caucasian	IBD	1360 (25.2)	758 (25.7)	0.975 (0.844-1.126)	0.580
				CD	641 (24.9)		0.964 (0.812-1.144)
				UC	665 (25.4)		0.991 (0.837-1.173)
8	McGovern et al[25]	2005	Caucasian	IBD	664 (26.6)	335 (31.8)	0.777 (0.634-0.952)	0.195
				CD	358 (24.4)		0.694 (0.548-0.878)
				UC	306 (29.1)		0.880 (0.693-1.117)

OR: Odds ratio; IBD: Inflammatory bowel disease; CD: Crohn’s disease; UC: Ulcerative colitis.