Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells

Table 1 Mammalian chitinases in inflammatory disorders

Location	Disorders	Chitinase type	Ref.
Airway	Bacteremia with S. pneumoniae	CHI3L1	[91,92]
	Bronchial asthma	CHI3L1, AMCase, Ym1	[14,38]
	COPD	CHI3L1	[93]
	Cystic fibrosis	AMCase, CHIT1	[94]
	Rhinosinusitis	AMCase	[95]
	Sarcoidosis	CHIT1	[96,97]
Blood	Bacterial septicemia	CHI3L1	[98]
Brain	Encephalitis	CHI3L1	[99,100]
	Meningitis	CHI3L1	[99]
Disc/Joint	Intervertebral disc degeneration	CHI3L1	[101]
	Juvenile idiopathic arthritis	CHIT1	[102]
	Osteoarthritis, RA	CHI3L1	[103,104]
Eye	Conjunctivitis	AMCase	[105,106]
GI tract	Helicobacter gastritis	CHI3L1, CHIT1	[107,108]
	Inflammatory bowel disease	CHI3L1	[10,109]
Heart	Acute myocardial infarction	CHI3L3, CHI3L1	[110,111,112]
	Coronary artery disease	CHIT	[113]
Liver	Chronic hepatitis C, LC	CHI3L1	[114,115]
	Fatty liver disease	CHIT1	[116,117]
	Hepatic fibrosis	CHI3L1	[118]
Oral cavity	Periodontitis	Chitinase	[119,120]
Systemic	Gaucher disease	CHIT1	[27]
	Systemic sclerosis	CHI3L1	[121,122]

COPD: Chronic obstructive pulmonary disease; LC: Liver cirrhosis; RA: Rheumatoid arthritis; CHI3L1: Chitinase 3-like-1; AMCase: Acidic mammalian chitinase; CHIT1: Chitotriosidase; Ym1: Chitinase-like lectin.