Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. May 14, 2009; 15(18): 2184-2189
Published online May 14, 2009. doi: 10.3748/wjg.15.2184
Table 1 STATs activation and function
STAT proteinActivating factorActivation effect
STAT 1IFN-α/β (type I INF) IFN-γ (type II INF)Antiviral response, inflammation and hepatocyte damage development, apoptosis stimulation
STAT 2INF-α/β i INF-λAntiviral response
STAT 3IL-6 and its family, IL-10, IL-22, EGF, HCV proteinsParticipates in antiviral IFN-α effect, direct cytoprotective and anti-inflammatory influence on hepatocytes
STAT 4IL-12Probably plays a critical role in hepatocytes damage during hepatic ischemia/reperfusion injury and in Th1 differentiation
STAT 5Growth factorsRegulates the genes expression essential for hepatocytes metabolism, growth and differentiation
STAT 6IL-4, IL-12 and IL-13Participates in Th2 lymphocytes response during viral hepatitis and decreases hepatocytes damage during hepatic ischemia/reperfusion injury