Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation

Figure 6 FXR activation induces CSE gene expression and regulated CSE activity in the liver with cirrhosis. FXR +/+ and FXR -/- mice were treated with CCl₄ and 6E-CDCA as described in the methods section. A and B: Quantitative real-time PCR of CSE mRNA and α1-collagen mRNA from FXR +/+ and FXR -/- liver homogenates; C: Liver CSE activity; D: Liver H₂S production. Data are mean ± SD of six mice. ^aP < 0.05 versus FXR+/+ control mice. ^cP < 0.05 versus CCl₄ FXR +/+ mice. ^eP < 0.05 versus FXR -/- control mice. ^gP < 0.05 versus CCl₄ FXR -/- mice.