Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. May 7, 2009; 15(17): 2049-2066
Published online May 7, 2009. doi: 10.3748/wjg.15.2049
Table 3 Additional biochemical markers that have been investigated in relation to ICP
Number of cases (controls)GestationParameter investigatedMain findingsReferences
76NRSerum human placental lactogen and AFP↑ hPL, no difference in AFP[88]
6837-38/40Pregnancy specific β-1-glycoprotein↓ Levels[89]
76 (150)T3Prolactin↑ Prolactin from 33 wk[94]
10 (288)T3Placental protein 10↓ Placental protein 10 in ICP-negatively correlated with AST and SBA[98]
NRT3 + PNSerum copper and zinc↑ Copper in ICP[91]
No difference in zinc
NRT3Serum 25(OH)D, 24, 25(OH)D, 1, 25(OH)D, total protein, calcium, phosphorus, magnesium and alkaline phosphatase25(OH)D initially higher in patients than controls, but decreased by delivery[92]
No change in any other parameter
12 (12)T3Serum selenium and glutathione peroxidase↓ Selenium in ICP[90]
↓ Glutathione peroxidase activity
33 (5680)T2Serum AFP and hCGNo differences[87]
26 (13)NRThyroid hormones↓ T3[93]
21 (98)T3Serum selenium, zinc and copper↓ Selenium in ICP[96]
↑ (Double) copper in ICP
No difference in zinc
72 (30)T3Renal function tests: uric acid, urea, potassium, sodium, creatinine↑ Uric acid and creatinine[97]
22 (21)NRMaternal-fetal mixed lymphocyte reaction↓ Transformation rate of lymphocytes[86]
24 (1148)T3Serum AFP and β-hCGNo differences[95]
30 (30)T3Serum neopterin and soluble interleukin 2 receptor (sIL-2R)↑ Neopterin and sIL-2R[99]
58 (42)T3Alpha-hydroxybutyrate dehydrogenase (α-HBDH) activity↑α-HBDH[100]