Down-regulation of extracellular signal-regulated kinase 1/2 activity in P-glycoprotein-mediated multidrug resistant hepatocellular carcinoma cells

doi:10.3748/wjg.15.1443

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Mar 28, 2009 (publication date) through Jul 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2009; 15(12): 1443-1451
Published online Mar 28, 2009. doi: 10.3748/wjg.15.1443

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Figure 1 Measurement of cellular sensitivity to anticancer drugs and parental cells. Cytotoxicity assay for adriamycin, fluorouracil, cyclophosphamide, tested cisplatin, mitomycin, and vincristine was performed to evaluate the IC50 for HepG2 and HepG2/ADM cells (A), SMMC7721 and SMMC7721/ADM cells (B). Dose response curves were derived from five independent experiments using MTT assay. The data were shown as mean ± SE.

Citation: Yan F, Wang XM, Pan C, Ma QM. Down-regulation of extracellular signal-regulated kinase 1/2 activity in P-glycoprotein-mediated multidrug resistant hepatocellular carcinoma cells. World J Gastroenterol 2009; 15(12): 1443-1451
URL: https://www.wjgnet.com/1007-9327/full/v15/i12/1443.htm
DOI: https://dx.doi.org/10.3748/wjg.15.1443