Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Oct 21, 2008; 14(39): 5945-5961
Published online Oct 21, 2008. doi: 10.3748/wjg.14.5945
Table 5 Studies on correlation of estrogen receptor and androgen receptor expression with clinical and pathological parameters in HCC patients
Receptor protein/mRNA expressionClinical parameternCountrySalient findingsYrReference
ER proteinSerum alpha-fetoprotein, carcinoembryonic antigen, HBV profile, tumor histology30JapanNo correlation with any parameter1986[13]
ER and AR proteinSerum alpha fetoprotein, HBV markers, histopathology19JapanNo correlation1989[15]
ER proteinSex, age, alcohol abuse, underlying liver disease, hepatic functions66JapanNo correlation1990[34]
Tumor size, hepatic resectionLarge tumor size and higher rate of resection in ER-
HistopathologyNo differences in ER+ and ER-
Operative mortality, tumor recurrence, long-term survival rateSimilar in ER+ and ER-
ER and AR proteinIntrahepatic recurrence78JapanAR expression strongly associated with intrahepatic recurrence. Weak association with ER expression1995[72]
ER proteinSurvival after curative resection28GermanyNegative effect of an ER+ tumor on patient survival after curative resection1997[42]
Wild type and variant ER mRNASurvival96ItalySignificantly long survival in patients with wild type ERs than variant ERs2000[55]
AR proteinRecurrence rate45JapanSignificantly higher recurrence rates in AR+ group than AR-1989[15]
Survival rateSignificantly better survival rates in AR- patients than in AR+
AR proteinTumor size43SpainAR expression was significantly related to smaller tumor size1995[69]
Tumor recurrenceHigher tumor recurrence rates in surrounding tissues of AR+ than AR-
AR proteinTumor size and survival time32ChinaSurvival rate correlated inversely with the levels of AR expression1998[70]
AR levels had positive correlation with the tumor size