Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Sep 21, 2008; 14(35): 5377-5384
Published online Sep 21, 2008. doi: 10.3748/wjg.14.5377
Table 4 Clinical features of the main endocrine pancreatic tumors
Tumor (syndrome)Clinical features and diagnostic testsMEN-1 (%)Metastases (%)SnSRS (%)
InsulinomaSpontaneous or fasting hypoglycemia (Whipple's triad)8-101050
Positive fasting test (hypoglycemia with hyperinsulinism)
Gastrinoma (Zollinger-Ellison syndrome)Peptic ulcers, diarrhea, GERD, BAO > 15 mEq/h306080
Positive secretin test (serum gastrinemia > 200 ng/L within 10 min from secretin venous infusion, 2 U/kg per min)
VIP-oma (Verner Morrison syndrome)Severe watery diarrhea (> 1L/die), hypokalemia, hypochlorhydriaRare7080
GlucagonomaNecrolytic migratory erythema, diabetes, weight loss, anemia, hypoaminoacidemia, venous thrombosisRare6080
SomatostatinomaDiarrhea, steatorrhea, weight loss, diabetes, cholelithiasisNot associated8480
CRH/ACTH-omaCushing's syndrome-90-