Incidence of gallstone disease in Italy: Results from a multicenter, population-based Italian study (the MICOL project)

Table 7 Distribution of symptoms (and unadjusted ORs) in gallstone-free subjects, patients with gallstones not previously diagnosed, patients with a previous diagnosis of gallstones, and patients with a history of cholecystectomy for gallstones

Symptoms (%) OR (95% CI)	Gallstone-free subjects (n = 9001)	Gallstones not previously diagnosed (n = 312)	Gallstones previously diagnosed (n = 112)	Cholecystectomized (n = 61)
Belching	19.1	19.5	27.2	23.1
		1.03 (0.75-1.39)	1.27 (0.86-1.89)	0.92 (0.48-1.75)
Heartburn	32.2	33.1	37.5	44.2
		1.12 (0.85-1.39)	0.89 (0.61-1.30)	1.29 (0.72-2.03)
Nausea	12.3	14.3	18.4	26.9
		1.22 (0.82-1.82)	1.48 (0.90-2.42)	2.40 (1.19-4.83)
Vomiting	7.2	7.7	9.6	9.6
		0.99 (0.59-1.64)	0.79 (0.41-1.53)	0.97 (0.40-2.33)
Bloated feeling after meals	37.2	38.6	44.9	48.1
		1.24 (0.95-1.61)	1.12 (0.78-1.63)	1.24 (0.69-2.21)
Epigastric discomfort	33.8	33.1	40.4	38.5
		0.96 (0.72-1.26)	1.26 (0.87-1.83)	0.87 (0.48-1.59)
Bitter taste in the morning	36.4	35.4	41.2	44.2
		0.93 (0.71-1.21)	0.88 (0.61-1.26)	1.08 (0.61-1.88)
Heavy feeling on the right side	19.7	18.8	25.7	28.8
		0.94 (0.68-1.29)	1.14 (0.77-1.71)	1.09 (0.58-2.05)
Heavy feeling in the epigastrium	22.7	21.3	25.0	26.9
		0.83 (0.60-1.15)	0.81 (0.53-1.24)	0.67 (0.34-1.33)
Pain in the epigastrium	11.2	24.7	39.0	51.2
		1.5 (1.17-2.4)	3.0 (2.6-5.7)	29.9 (7.0-221.3)
Pain in the right hipocondrium	15.8	23.7	39.0	46.5
		1.7 (1.3-2.8)	3.9 (3.1-7.4)	32.1 (9.3-238.9)
Intolerance to fatty or fried foods	24.0	5	4.4	3.4
		0.99 (0.63-1.55)	0.94 (0.19-1.79)	1.04 (0.5-2.14)