Inflammatory cytokines suppress arylamine N-acetyltransferase 1 in cholangiocarcinoma cells

Figure 1 The effect of a mixture of inflammatory cytokines on NAT1 activity in KKU-100 cells. Assays were performed with the cytosol fraction extracted from KKU-100 cells and treated with a combination of cytokines for 48 h. A: Kinetic analysis of NAT1 activity; B: Activity of NAT1 at various substrate concentrations (PABA) of KKU-100 cells with or without treatment with cytokines. ^aP < 0.05 between cytokine treated and control groups.