Red wine and green tea reduce H pylori- or VacA-induced gastritis in a mouse model

Figure 3 Representative images of sections of gastric corpus mucosa of mice treated with 50 μg of VacA in the presence (A-D) or in the absence (E and F) of RW or GT as indicated, in comparison with saline-treated control (G and H). HE staining (A, C, E and G): VacA control (E) shows a typical loss of mucosal architecture, with areas of cellular debris and inflammatory cells admixture (arrowhead), almost undetectable in the presence of RW (A) or GT (C). IHC detection of VacA (B, D, F and H): distribution of VacA upon RW treatment (B) is both superficial and deep, similarly to that of VacA-treated control (F), while upon GT treatment (D) VacA is detectable only on the surface of gastric epithelium.