Amplification of D22S283 as a favorable prognostic indicator in liver fluke related cholangiocarcinoma

Table 3 Cox regression analysis using univariate and multivariate models in CCA patients

Variables	Categories	Univariate analysis		Multivariate analysis
		P-value	HR (95% CI)	P-value	HR (95% CI)
Stage	IVa + IVb vs II + III	NS	1.560 (0.660-3.690)
Histology	Poorly vs Unclassified	NS	1.152 (0.507-2.619)
	Moderate vs Unclassified	NS	0.994 (0.473-2.087)
	Well diff vs Unclassified	NS	0.929 (0.429-2.013)
Vessel invasion	Yes vs No	0.021	2.080 (1.120-3.877)	0.042	1.911 (1.022-3.571)
Nerve invasion	Yes vs No	NS	1.328 (0.770-2.293)
Lymphatic invasion	Yes vs No	NS	1.591 (0.716-3.536)
TP	Deletion vs Normal	NS	0.791 (0.314-1.997)
	Amplification vs Normal	NS	1.034 (0.576-1.857)
D22S274	Deletion vs Normal	NS	1.186 (0.625-2.250)
	Amplification vs Normal	NS	0.869 (0.439-1.718)
BIK	Deletion vs Normal	NS	1.271 (0.704-2.294)
	Amplification vs Normal	NS	1.714 (0.771-3.810)
TOB2	Deletion vs Normal	NS	1.176 (0.277-4.995)
	Amplification vs Normal	NS	0.945 (0.545-1.641)
ST13	Deletion vs Normal	NS	0.913 (0.466-1.788)
	Amplification vs Normal	NS	0.938 (0.500-1.761)
D22S423	Deletion vs Normal	NS	1.183 (0.667-2.097)
	Amplification vs Normal	NS	0.896 (0.366-2.192)
D22S283	Deletion vs Normal	NS	0.793 (0.397-1.585)
	Amplification vs Normal	0.003	0.384 (0.202-0.728)	0.006	0.411 (0.217-0.779 )
TIMP3	Deletion vs Normal	NS	1.758 (0.527-5.864)
	Amplification vs Normal	NS	0.736 (0.418-1.296)
NF2	Deletion vs Normal	NS	0.929 (0.420-2.055)
	Amplification vs Normal	NS	0.621 (0.344-1.122)