Extremely well-differentiated adenocarcinoma of the stomach: Clinicopathological and immunohistochemical features

Figure 2 An early lesion of extremely well-differentiated adenocarcinoma of the stomach, complete intestinal-type (case 8). A: Macroscopic view showing a shallow depressed lesion with an irregular margin; B: carcinoma invasion to the submucosal layer (low-power view); C and D: carcinoma mimicking the intestinal metaplasia of complete-type with basally located small nuclei, eosinophilic cytoplasm and scattered goblet cells. Note the irregular arrangement of glands and intraluminal debris; E: CD10 positivity of carcinomatous glands along the luminal surfaces; and F: MUC2 positivity of scattered goblet cells.