Effect of verapamil on nitric oxide synthase in a portal vein-ligated rat model: Role of prostaglandin

Table 2 Effect of verapamil in combination with NNA, INDO, and NNA plus INDO on systemic and splanchnic haemodynamics in PVL rats (mean±SE)

	Verapamil		Verapamil+NNA		Verapamil+INDO		Verapamil+NNA+INDO
	(n = 8)		(n = 8)		(n = 7)		(n = 8)
	Before	After	Before	After	Before	After	Before	After
CI[mL/(min.kg)]	423 ± 38	298 ± 42a	425 ± 41	312 ± 48a	424 ± 39	332 ± 51a	426 ± 40	326 ± 49a
MAP(mmHg)	105 ± 5	96 ± 6a	106 ± 6	99 ± 7a	107 ± 4	98 ± 7a	106 ± 8	100 ± 7a
PP(mmHg)	15.0 ± 1.6	10.8±1.9a	14.3 ± 1.8	13.8 ± 2.1	15.2 ± 1.9	14.5 ± 2.4	15.1 ± 1.6	14.6 ± 1.4
PVI(mL/min)	27 ± 2.8	26 ± 3.2	26 ± 2.7	25 ± 3.4	28 ± 3.1	27 ± 3.5	27 ± 3.2	26 ± 3.9
HAF(mL/min)	7 ± 1.6	8 ± 1.8	8 ± 1.8	9 ± 2.2	7 ± 1.9	8 ± 2.2	9 ± 2.0	9 ± 2.8
PSS(%)	81.7 ± 7.2	63.6 ± 8.2a	80.2 ± 8.3	76.5 ± 9.2	81.2 ± 6.2	77 ± 7.8	80.5 ± 6.6	76.2 ± 9.5

CI: cardiac index; MAP: mean arterial pressure; PP: portal pressure; HAF: hepatic arterial flow; PSS:portalsyste-mic shunting; NNA: N^w-nitro–L-arginine; INDO: indomethacin; ^aP < 0.05 vs control group.