Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor κB expression and enhanced antiapoptosis-related proteins in Helicobacter pylori-infected non-cardiac gastric adenocarcinoma

Table 2 8-oHdG, iNOS, NFκB, Mel-1 and IAP Concentrations in cancer and adjacent non-cancer tissues

	Cancertissue	H pylori (+)	Stages I & II	Stages III & IV
8-OHdG	↑a	↑a	-	↑a
iNOS	↑b	↑b	-	↑b
NF-κB	↑a	↑a	-	↑a
MEKK1	-	-	-	-
Caspase 3	-	-	↓b	-
Bcl-2	-	-	↓b	-
Mcl-1	↑a	↑a	-	↑a
IAP	↑a	↑a	-	↑a

↑: increase, ↓: decrease, -: no significant change, ^aP < 0.05, ^bP < 0.01 compared with control, by one sample t-test and independent t-test, respectively.