Interleukin-10 modified dendritic cells induce allo-hyporesponsiveness and prolong small intestine allograft survival

Figure 1 Inhibitory effect of IL-10-DC on allogenic T cell proliferation. ^aP < 0.05, ^bP < 0.01, vs DC group.

Figure 2 Flow cytometric analysis for apoptotic T cells induced by IL-10-DC.

Figure 3 Survival (%) of recipient small intestines from control group (n = 6), untransduced DC group (n = 6) and IL-10-DC group (n = 6).

Figure 4 Histological comparison of allografts between control group rats and IL-10-DC pretreated rats. Control group showed acute rejection sign on POD 3 (A) and mucosal sloughing and necrosis and destruction of normal glandular architecture on POD 7 (B). IL-10-DC group demonstrated mild lymphocyte infiltration and blunting of villi with edema on POD 7 (C) and fibroblastic proliferation extending from the submucosa to the lamina muscularis (D). (hematoxylin-erosin staining, × 200).