Effect of tetramethylpyrazine on exocrine pancreatic and bile secretion

Figure 1 Effect of TMP on Volume of pancreatic-bile juice secretion. The volume of pancreatic-bile juice secretion collected before (basal) and 15, 30, 45, 60 and 75 min after intraperitoneal administration of TMP (80 mg/kg) and 9 mL/L NaCl in rats. The results were expressed as ¯x ± S_-x. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, as compared to basal values.

Figure 2 Concentration-response curve for TMP-induced I_SC in CAPAN-1 cells. Different concentrations of TMP were added to basalateral side. Each data point was obtained from at least 4 individual experiments. Arrow shows EC₅₀.

Figure 3 TMP-induced HCO₃^- secretion in CAPAN-1 cells. Comparison of TMP (5 mmoL/L)-induced I_SC (mC/cm²) obtained in control (A, C), pretreatment with DPC (1 mmoL/L) (B, C), Amiloride 100 umoL/L (C), HCO₃^--free solution (D), Cl^--free solution (D), Values are ¯x ± S_-x, ^aP < 0.05, ^cP < 0.001.

Figure 4 Pretreatment with IBMX decreased TMP-induced I_SC by 91%. Values are ¯x ± S_-x, ^cP < 0.001