Advances and controversies in the management of T4 colon cancer

Figure 1 Survival curves of patients with colorectal cancers according to r-pathological staging category. A: Survival curves of patients in pathological staging (pT) 3 and pT4a. There were no significant differences between pT3/sT4b and pT4a/sT1-4a (P = 0.599), or between pT4a/sT4b and pT4b (P = 0.351); B: Survival curves of patients stratified by r-pT category. There were significant differences among the patients. pT: Pathological staging. Citation: Liang JW, Gao P, Wang ZN, Song YX, Xu YY, Wang MX, Dong YL, Xu HM. The integration of macroscopic tumor invasion of adjacent organs into TNM staging system for colorectal cancer. PLoS One 2012; 7: E52269. Copyright ©The Author(s) 2012. Published by Public Library of Science (PLoS)[21]. The article is open access (Supplementary material).

Figure 2 Risk of recurrence or persistent disease. RR: Risk ratio; CI: Confidence interval; NAC: Neoadjuvant chemotherapy. Citation: Morton D, Seymour M, Magill L, Handley K, Glasbey J, Glimelius B, Palmer A, Seligmann J, Laurberg S, Murakami K, West N, Quirke P, Gray R; FOxTROT Collaborative Group. Preoperative Chemotherapy for Operable Colon Cancer: Mature Results of an International Randomized Controlled Trial. J Clin Oncol 2023; 41: 1541-1552. Copyright ©The Author(s) 2023. Published by American Society of Clinical Oncology[23]. The article is open access (Supplementary material).