Retrospective Study
Copyright ©The Author(s) 2023.
World J Gastroenterol. Jan 28, 2023; 29(4): 706-730
Published online Jan 28, 2023. doi: 10.3748/wjg.v29.i4.706
Figure 1
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Figure 1 Fan charts and bar plots of the clinical characteristic. A-C: There were 24045 subjects who underwent health checkup and 8812 subjects with an active consultation.
Figure 2
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Figure 2 Histograms of carcinoembryonic antigen, carbohydrate antigen 19-9, and carbohydrate antigen 72-4. A: Carcinoembryonic antigen; B: Carbohydrate antigen 19-9; C: Carbohydrate antigen 72-4. CEA: Carcinoembryonic antigen; CA 19-9: Carbohydrate antigen 19-9; CA 72-4: Carbohydrate antigen 72-4.
Figure 3
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Figure 3 Boxplots of biomarker levels of malignant tumors. The red dotted line is the biomarker level for all subjects. The P value was calculated between the malignant tumor patients and the subjects without any malignant tumors by the Wilcoxon test. aP < 0.05, bP < 0.01. CEA: Carcinoembryonic antigen; CA 19-9: Carbohydrate antigen 19-9; CA 72-4: Carbohydrate antigen 72-4.
Figure 4
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Figure 4 Boxplots of biomarker levels for each stage of gastric cancer and colorectal cancer. A: Carcinoembryonic antigen; B: Carbohydrate antigen 19-9; C: Carbohydrate antigen 72-4. CEA: Carcinoembryonic antigen; CA 19-9: Carbohydrate antigen 19-9; CA 72-4: Carbohydrate antigen 72-4; CIS: Carcinoma in situ.
Figure 5
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Figure 5 Receiver operating characteristic curves of carcinoembryonic antigen, carbohydrate antigen 19-9, and carbohydrate antigen 72-4 for gastric cancer, colorectal cancer and gastrointestinal cancers. A-C: Carcinoembryonic antigen; D-F: Carbohydrate antigen 19-9; G-I: Carbohydrate antigen 72-4. CEA: Carcinoembryonic antigen; CA 19-9: Carbohydrate antigen 19-9; CA 72-4: Carbohydrate antigen 72-4.
Figure 6
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Figure 6 Decision curves of tumor biomarkers for gastrointestinal cancers. A-C: Carcinoembryonic antigen; D-F: Carbohydrate antigen 19-9; G-I: Carbohydrate antigen 72-4. CEA: Carcinoembryonic antigen; CA 19-9: Carbohydrate antigen 19-9; CA 72-4: Carbohydrate antigen 72-4.
Figure 7
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Figure 7 Economic analysis of tumor biomarkers in six schemes for gastrointestinal cancers. A and B: Carcinoembryonic antigen; C and D: Carbohydrate antigen 19-9; E and F: Carbohydrate antigen 72-4. CEA: Carcinoembryonic antigen; CA 19-9: Carbohydrate antigen 19-9; CA 72-4: Carbohydrate antigen 72-4.
Figure 8
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Figure 8 Bar plots of subgroup analysis of economic indicators for carcinoembryonic antigen. A and B: Whole; C and D: Health checkup; E and F: Active consultation.
Figure 9
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Figure 9 Bar plots of subgroup analysis of economic indicators for carbohydrate antigen 19-9. A and B: Whole; C and D: Health checkup; E and F: Active consultation.
Figure 10
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Figure 10  Bar plots of subgroup analysis of economic indicators for carbohydrate antigen 72-4. A and B: Whole; C and D: Health checkup; E and F: Active consultation.