Clinicopathological features and prognostic factors associated with gastroenteropancreatic mixed neuroendocrine non-neuroendocrine neoplasms in Chinese patients

Figure 1 Histopathological and immunohistochemical findings of gastroenteropancreatic mixed neuroendocrine-non-neuroendocrine neoplasms. A: Neuroendocrine carcinoma (left) and adenocarcinoma (right) (Hematoxylin-eosin staining, scale bar 200 µm); B: Adenocarcinoma component (Hematoxylin-eosin staining, scale bar 200 μm); C: Neuroendocrine component (Hematoxylin-eosin staining, scale bar 100 μm); D: Cytokeratin-positive adenocarcinoma (EnVision, scale bar 100 μm); E: CgA-positive neuroendocrine (EnVision, scale bar 100 μm); F: Syn-positive neuroendocrine (EnVision, scale bar 100 μm).

Figure 2 Kaplan-Meier curves of overall survival among 46 patients with gastroenteropancreatic mixed neuroendocrine-non-neuroendocrine neoplasms. Overall survival grouped by A: Age (P = 0.028); B: Tumor size (P = 0.024); C: Ki-67 index (P = 0.002); D: Proportions of NEC and adenocarcinoma (P = 0.002); E: Adenocarcinoma differentiation (P = 0.001); F: Lymph node metastasis (P = 0.003); G: Vascular tumor thrombus (P < 0.001); H: Nerve invasion (P = 0.001); I: Distant metastasis (P < 0.001); and J: Clinical stage (P < 0.001); K: Overall survival of 46 patients with gastroenteropancreatic mixed neuroendocrine-non-neuroendocrine neoplasms.