Development and validation of a prognostic model for patients with hepatorenal syndrome: A retrospective cohort study

Figure 1 Workflow. The eligible cohort selection process after applying the inclusion and exclusion criteria from four hospitals. HRS: Hepatorenal syndrome.

Figure 2 Characteristics associated with survival. A: Importance of each characteristic of GIMNS; B: Mosaic plot. Survival status of patients with different causes of cirrhosis, gender, and stage. HBV: Hepatitis B virus; INR: International normalized ratio; MCHC: Mean corpuscular hemoglobin concentration.

Figure 3 Kaplan–Meier curves of variables of GIMNS. A: Stratified international normalized ratio; B: Stratified neutrophil percentage; C: Stratified mean corpuscular hemoglobin concentration; D: Stage; E. Gender. INR: International normalized ratio; MCHC: Mean corpuscular hemoglobin concentration.

Figure 4 Distributions of the GIMNS score. A: The GIMNS score distribution between survivors and non-survivors in the derivation and validation cohorts; B: Kaplan–Meier curves of GIMNS.

Figure 5 Relationship between GIMNS and other scoring systems and receiver operating characteristic curve curves. A: GIMNS and Model for End-stage Liver Disease; B: GIMNS and Chronic Liver Failure-Sequential Organ Failure Assessment; C: GIMNS and Chinese Group on the Study of Severe Hepatitis B-Acute-on-Chronic Liver Failure; D: Receiver operating characteristic curve curves in derivation cohort; E: Receiver operating characteristic curve in validation cohort. CLIF-SOFA: Chronic Liver Failure-Sequential Organ Failure Assessment; COSSH-ACLF: Chinese Group on the Study of Severe Hepatitis B-Acute-on-Chronic Liver Failure; MELD: Model for End-stage Liver Disease; AUC: Area under the curve.