Advanced small-bowel well-differentiated neuroendocrine tumours: An international survey of practice on 3rd-line treatment

Figure 1 Summary of treatment predominant flow by line of therapy. SSA: Somatostatin analogues; PRRT: Peptide receptor radionuclide therapy; Liver embol: Liver embolization; HD-SSA: High-dose of somatostatin analogues.

Figure 2 Factors associated with treatment decision making process. A: Factors associated with use of somatostatin analogues in the first-line setting; B: Factors associated with use of peptide receptor radionuclide therapy in the second-line setting; C: Factors associated with use of everolimus; D: Factors associated with use of chemotherapy; E: Factors associated with use of liver embolization; F: Factors associated with use of Interferon-alpha. SSA: Somatostatin analogues; SSTR2 –ve: Somatostatin receptor positive disease (imaging based); SSTR2 +ve: Somatostatin receptor negative disease (imaging based); heter: Heterogeneous; mts: Metastases; m: months; TOTAL: Represents the average of all factors; PRRT: Peptide receptor radionuclide therapy.

Figure 3  Ongoing controversies around use of peptide receptor radionuclide therapy in current practice.