Annexin A2 promotion of hepatocellular carcinoma tumorigenesis via the immune microenvironment

Figure 1 Involvement of Annexin A2 in the change of immune microenvironment. A: The expression of ANXA2 mRNA according to The Cancer Genome Atlas database; B: Increased ANXA2 results in poorer 5-year overall survival; C: The proportion of 22 infiltrating immune cells; D: Gene ontology analysis of differentially expressed genes. ANXA2: Annexin A2; HCC: Hepatocellular carcinoma.

Figure 2 Increased Annexin A2 promotes immune escape in hepatocellular carcinoma patients. A: Correlation of partial labeled genes of regulatory T cells; B: Correlation of partial labeled genes of activated natural killer cells; C: Correlation of partial labeled genes of activated dendritic cells; D: The expression of partial checkpoint molecules; E: The expression of partial inhibitory molecules and effector molecules. ANXA2: Annexin A2; NK: Natural killer.