Integrative analysis of the inverse expression patterns in pancreas development and cancer progression

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Figure 1 Continuous differential expression patterns in pancreas development. A: Clustering of human pancreas development genes. In the heat map, green indicates down-regulated, and red indicates up-regulated. In the line graphs, lines represent the tendency of the cluster changes; B: Gene Ontology-Biological Process annotations of the continuously up- and down-regulated genes.

Figure 2 The expression patterns identified from GSE96697. Among these results, up- and downregulated patterns (red, green color labeled) were defined and further analyzed in our study.

Figure 3 The expression patterns identified from six pancreatic cancer datasets. A: Among these results, up- and downregulated patterns (red, blue color labeled) were defined and further analyzed in our study; B: Pie diagram showed the up- and down-regulation genes in each pancreatic cancer dataset.

Figure 4 Integrated analysis of expression patterns in pancreas development and pancreatic cancer progression. A: Comparison of interpretation patterns between pancreas development and cancer progression. Color in each cell indicated the p-value; B: Gene Ontology-Biological Process annotations of the inverse interpretation patterns, including dev-up vs can-dw and dev-dw vs can-up.