Comparison of TPMT and NUDT15 polymorphisms in Chinese patients with inflammatory bowel disease

Figure 1 Study design. ¹Adverse reactions included leukopenia (white blood cell count < 3.5 × 10⁹/L or neutrophils < 1.5 × 10⁹/L), hepatoxicity, severe gastrointestinal adverse reactions and severe hair loss; ²Drug dose was increased by 0.5 mg/kg daily every month gradually to 1.0-2.0 mg/kg daily. AZA: Azathioprine; IBD: Inflammatory bowel disease.

Figure 2 Gene polymorphism frequency distributions of TPMT and NUDT15. ^aP < 0.05 vs mutant type of TPMT group.

Figure 3 Occurrence of leukopenia with different genotypes of NUDT15 (A) and TPMT (B). ^aP < 0.05 vs NUDT15 C/C developed leukopenia group.