Performance of transient elastography in assessing liver fibrosis in patients with autoimmune hepatitis-primary biliary cholangitis overlap syndrome

Figure 1 Correlation between liver stiffness measurement and histological fibrosis stage. LSM values were assessed by TE in healthy normal controls and AIH-PBC overlap syndrome patients with different liver fibrosis stages based on the results of liver biopsy (F0-4). ^aP < 0.01, F2, 3, and 4 vs NC; ^bP < 0.01, F3 vs F2; ^cP < 0.01, F4 vs F3. LSM: Liver stiffness measurement; NC: Normal controls; AIH-PBC: Autoimmune hepatitis-primary biliary cholangitis; TE: Transient elastography.

Figure 2 The receiver operator characteristic curve of liver stiffness measurement for the diagnosis of liver fibrosis stage. A: Significant fibrosis (F ≥ 2); B: Severe fibrosis (F ≥ 3); C: Cirrhosis (F4).

Figure 3 The receiver operator characteristic curves of liver stiffness measurement, fibrosis-4, aspartate aminotransferase-to-platelet ratio index, and GRP for the detection of severe fibrosis (F ≥ 3). LSM: liver stiffness measurement; GPR: GGT/platelet ratio; FIB-4: Fibrosis-4; APRI: Aminotransferase -to-platelet ratio index.