Evaluation of elastography combined with serological indexes for hepatic fibrosis in patients with chronic hepatitis B

Figure 1 Histopathology of different pathological stages of hepatic fibrosis. S0 phase: No fibrosis; S1 phase: Fibrous enlargement in the portal area, but no fibrillary septum formation; S2 phase: Fibrosis enlargement in the portal area, a few fibrous septae formed; S3 stage: Most fibrous septae formed but no hardened nodules; S4 stage: Liver cirrhosis.

Figure 2 Image of hepatic fibrosis assessed by acoustic radiation force impulse to assess liver tissue elasticity. A: Normal liver tissue, SWV = 1.01 m/s; B: Mild hepatic fibrosis, SWV = 2.03 m/s; C: Moderate hepatic fibrosis, SWV = 2.97 m/s; D: Severe hepatic fibrosis, SWV = 4.01m/s. ARFI: Acoustic radiation force impulse.

Figure 3 Receiver operating characteristic curve for the diagnosis of hepatic fibrosis based on different indicators. APRI: Aspartate aminotransferase-to-platelet ratio index; AST: Aspartate transaminase; ALT: Alanine aminotransferase; CIV: Type IV collagen; FIB-4: Fibrosis index based on the 4 factor; HA: Hyaluronic acid; SWV: Shear wave velocity.

Figure 4 Receiver operating characteristic curve for the diagnosis of hepatic fibrosis based on different combined indicators.