Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma

doi:10.3748/wjg.v24.i18.1989

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2018; 24(18): 1989-1994
Published online May 14, 2018. doi: 10.3748/wjg.v24.i18.1989

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Figure 1 Developmental process of hepatocellular carcinoma via nonalcoholic steatohepatitis. Based on excessive lipids accumulation, several factors such as inflammatory cytokines, oxidative stress or proliferating pathways are involved in the whole process of hepatocellular carcinoma development from nonalcoholic steatohepatitis status via nonalcoholic fatty liver disease. NAFLD: Nonalcoholic fatty liver disease; HCC: Hepatocellular carcinoma; NASH: Nonalcoholic steatohepatitis.

Citation: Takakura K, Oikawa T, Tomita Y, Mizuno Y, Nakano M, Saeki C, Torisu Y, Saruta M. Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma. World J Gastroenterol 2018; 24(18): 1989-1994
URL: https://www.wjgnet.com/1007-9327/full/v24/i18/1989.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i18.1989