Anti-integrin therapy for inflammatory bowel disease

Figure 1 Process of leukocyte migration through the endothelium. Leukocytes moving in the blood begin to tether and roll at a specific site of the vessel wall, undergo activation, arrest and adhesion to the vascular endothelial cells, eventually migrate between the endothelial cells.

Figure 2 Therapeutic targets of anti-integrin agents[14]. VCAM-1: Vascular cellular adhesion molecule-1; MadCAM-1: Mucosal addressin cellular adhesion molecule-1.