Prognostic significance of preoperative and postoperative CK19 and CEA mRNA levels in peripheral blood of patients with gastric cardia cancer

Figure 1 Receiver operating characteristic curves for preoperative and postoperative cytokeratin 19 and carcinoembryonic antigen mRNA levels in patients with gastric cardia cancer according to overall survival. A: Preoperative CK19 mRNA level; B: Postoperative CK19 mRNA level; C: Preoperative CEA mRNA level; D: Postoperative CEA mRNA level. AUC: Area under the curve; CK19: Cytokeratin 19; CEA: Carcinoembryonic antigen; ROC: Receiver operating characteristic.

Figure 2 Kaplan-Meier survival curves according to preoperative and postoperative cytokeratin 19 and carcinoembryonic antigen mRNA levels in patients with gastric cardia cancer. A: Preoperative CK19 mRNA level; B: Postoperative CK19 mRNA level; C: Preoperative CEA mRNA level; D: Postoperative CEA mRNA level. P values were calculated by the log-rank test and P < 0.05 denoted significance. OS: Overall survival; CK19: Cytokeratin 19; CEA: Carcinoembryonic antigen.

Figure 3 Cumulative survival curves for 129 patients with gastric cardia cancer according to risk groups by Kaplan-Meier survival analysis. The 5-year OS rates for the low-, intermediate-, and high-risk groups were 48.3%, 22.6% and 4.6%, respectively (P < 0.001). OS: Overall survival.