Changes with aging in gastric biomarkers levels and in biochemical factors associated with Helicobacter pylori infection in asymptomatic Chinese population

Figure 1 Comparison of serum gastric biomarker levels in various age groups. There was no significant difference in serum levels of PGI and G-17 between each age group with increasing age. In contrast, serum levels of PGII increased with age, and were significantly higher in subjects ≥ 65-years-old compared to 35-44-years-old group. The ratio of PGI/PGII decreased with age, and was significantly lower in subjects ≥ 75-years-old compared to 35-44-years-old group. The “a” denotes comparison with 35-44-years-old age group, ^aP < 0.05, ^bP < 0.01. G-17: Gastrin-17; PGI: Pepsinogen I; PGII: Pepsinogen II.

Figure 2 Comparison of serum gastric biomarker levels by Helicobacter pylori infection status. Compared to non-infected subjects, serum levels of PGI, PGII and G-17 were significantly higher, while the ratio of PGI/PGII was significantly lower in Helicobacter pylori-infected subjects. ^aP < 0.05, ^bP < 0.01. G-17: Gastrin-17; PGI: Pepsinogen I; PGII: Pepsinogen II.

Figure 3 Comparison of serum cholesterol levels in various age groups by Helicobacter pylori infection status. In H. pylori-infected subjects, serum levels of TC and LDL were significantly higher in subjects between 55- and 74-years-old compared to those in the 35-44-years-old age group. In non-infected subjects, serum levels of TC and LDL were significantly higher in subjects between 45- and 64-years-old compared to those in the 35-44-years-old age group. The “a” denotes comparison with the 35-44-years-old age group and the “b” denotes comparison with the 45-54-years-old age group, ^aP < 0.05, ^bP < 0.01. H. pylori: Helicobacter pylori; LDL-C: Low-density lipoprotein cholesterol; TC: Total cholesterol.