Inflammatory bowel disease incidence in Czech children: A regional prospective study, 2000-2015

Figure 1 Map of the catchment area, the geographical area under investigation for the Czech pediatric inflammatory bowel disease study over the period of 2000-2015. Outline of the Pilsen region (red) in the Czech Republic (orange) situated in central Europe.

Figure 2 Bar graph showing the total annual numbers of newly diagnosed Crohn’s disease, ulcerative colitis and inflammatory bowel disease-unclassified individuals (< 19 yr) in the Pilsen region, 2000-2015. CD: Crohn’s disease; UC: Ulcerative colitis; IBD-U: Inflammatory bowel disease-unclassified.

Figure 3 Age-specific incidence of all new-onset pediatric inflammatory bowel disease, Crohn’s disease, ulcerative colitis, and inflammatory bowel disease-unclassified per 100000 person-years (< 19 yr) in the Pilsen region, 2000-2015. The incidence of IBD significantly increased with age (P = 0.0003). IBD: Inflammatory bowel disease; CD: Crohn’s disease; UC: Ulcerative colitis; IBD-U: Inflammatory bowel disease-unclassified.

Figure 4 Scatter plots of the data. The average annual age-standardized incidence rate per 100000 person-years by age group (< 19 years) and the 16-year trend for inflammatory bowel disease (A), Crohn’s disease (B), and ulcerative colitis (C) in the Pilsen region over the period of 2000-2015 in the population under observation and the incidence rate projected for 2016-2018. The points are the actual data; Stars indicate the incidence of IBD (A), CD (B) and UC (C) per 100000 person-years; Blue points indicate calculating the moving average; Dotted blue line indicates a fitted linear regression model to predict trends; Triangles indicate the incidence rate projected for 2016-2018; Red points indicate calculating the moving average. There was a significant increase in incidence over the 16-year period (A: r = 0.32, P = 0.012; B: r = 0.42, P < 0.0001; C: r = - 0.15, P = 0.134).