Trefoil factor-3 is not a useful marker of mucosal healing in Crohn's disease treated with anti-TNF-α antibodies

Figure 1 Correlation of serum trefoil factor-3 concentrations with Simple Endoscopic Score for Crohn’s disease scores. Samples were collected from 29 patients before and after the induction therapy with anti-TNF-α agents (n = 58). TFF-3: Trefoil factor-3; SES-CD: Simple Endoscopic Score for Crohn’s disease.

Figure 2 Individual changes in serum trefoil factor-3 during anti-TNF-α therapy in patients with or without successful mucosal healing as assessed by endoscopy. MH: Mucosal healing; TFF-3: Trefoil factor-3.

Figure 3 Correlation of fecal calprotectin with Simple Endoscopic Score for Crohn’s disease and serum trefoil factor-3 in 10 patients assessed before and after the induction therapy with anti-TNF-α agents (n = 20). TFF-3: Trefoil factor-3; SES-CD: Simple Endoscopic Score for Crohn’s Disease; FC: Fecal calprotectin.