Combination of three-gene immunohistochemical panel and magnetic resonance imaging-detected extramural vascular invasion to assess prognosis in non-advanced rectal cancer patients

Figure 1 Representative examples of extramural vascular invasion and immunohistochemistry images in distinct prognostic groups. Overexpression of c-MYC and TIMP1 is a marker of better prognosis, whereas PCNA is a marker of poor prognosis, which was consistent with known biological roles.

Figure 2 Immunohistochemistry panel combined with magnetic resonance imaging-detected extramural vascular invasion enhanced the accuracy of prognoses for patients with rectal carcinoma. Combination of EMVI and the IHC panel separated patients into distinct prognostic groups (P < 0.01). EMVI: Extramural vascular invasion; IHC: Immunohistochemistry.