Cost effectiveness of routine duodenal biopsies in iron deficiency anemia

Figure 1 Quality adjusted life-years outcome. A: Influential parameters on the incremental quality adjusted life-years (QALY); B: One-way sensitivity analysis figure of the prevalence of celiac disease; C: One-way sensitivity analysis figure of the utility of celiac disease; D: One-way sensitivity analysis figure of the probability of diagnosing celiac disease due to symptoms. CD: Celiac disease; GFD: Gluten free diet; SBB: Small bowel biopsy.

Figure 2 Cost outcome. A: Influential parameters on the incremental cost; B: Two-way sensitivity analysis depicting the less costly strategy, in regards to serological tests and small bowel biopsies prices.

Figure 3 Incremental cost-effectiveness ratio outcome. A: Parameters that affected the incremental cost-effectiveness ratio (ICER) analysis; B: ICER of both strategies in regard to the cost of small bowel biopsies. CD: Celiac disease; GFD: Gluten free diet.

Figure 4 Validation. A: Monte Carlo simulation of 100 sample trials with 10000 patients in each trial; B: Acceptability curve that validate the cost effectiveness results of the study in relation to the willingness to pay for each quality adjusted life year (QALY). SBB: Small bowel biopsie.

Figure 5 Incremental cost-effectiveness ratio outcome in patients with negative celiac serology. A: Parameters that affected the incremental cost-effectiveness ratio (ICER) analysis; B: A one way sensitivity analysis of ICER in regards to the cost of small bowel biopsies. CD: Celiac disease; GFD: Gluten free diet.