Veterans health administration hepatitis B testing and treatment with anti-CD20 antibody administration

Figure 1 Proportion of all patients with pretreatment hepatitis B surface antigen (A) and hepatitis B core antibody (B) testing over time. Over the study period, pretreatment HBsAg testing within six months of anti-CD20 Ab initiation increased steadily, in parallel with pretreatment HBsAg testing obtained at any time. Over the study period, pretreatment HBcAb testing within six months of anti-CD20 Ab initiation steadily increased, in parallel with pretreatment HBcAb testing obtained at any prior time. HBsAg: Hepatitis B surface antigen; HBcAb: Hepatitis B core antibody.

Figure 2 Hepatitis B antiviral treatment by hepatitis B category. Mean hepatitis B antiviral treatment use during anti-CD20 Ab treatment and 12 mo follow-up is profiled by hepatitis B category throughout the study period.

Figure 3 Incidence of hepatitis and liver failure by hepatitis B category. The incidence of hepatitis and liver failure during anti-CD20 Ab treatment and 12 mo follow-up is profiled by hepatitis B category throughout the study period.

Figure 4 Mean peak ALT and bilirubin by hepatitis B category. The mean peak ALT and bilirubin of patients during anti-CD20 Ab treatment and 12 mo follow-up is profiled by hepatitis B category throughout the study period.

Figure 5 Incidence of overall, hepatitis-B associated, liver-related or cancer-related mortality by hepatitis B category. The overall, hepatitis-B associated, liver-related or cancer-related mortality incidence during anti-CD20 Ab treatment and 12 mo follow-up is profiled by hepatitis B category throughout the study period.