Calcium supplementation for the prevention of colorectal adenomas: A systematic review and meta-analysis of randomized controlled trials

Figure 1 Summary of the evidence search and selection process (flow diagram). RCTs: Randomized controlled trials.

Figure 2 Risk-of-bias assessment for the studies included in the meta-analysis. Green (+): Low risk-of-bias; Yellow (?): Unclear risk-of-bias. ECP: European Cancer Prevention Organisation; SWOG: Southwest Oncology Group.

Figure 3 Forest plot for adenomas: results from individual studies and meta-analysis. For the analysis we used intention-to-treat data for patients who underwent follow-up evaluation (follow-up colonoscopies). ECP: European Cancer Prevention Organisation; SWOG: Southwest Oncology Group; n: Number of subjects with at least one adenoma detected during the follow-up evaluation; N: Number of subjects who underwent follow-up evaluation; RR: Risk ratio.

Figure 4 Forest plot for advanced adenomas: results from individual studies and meta-analysis. For the analysis we used intention-to-treat data for patients who underwent follow-up evaluation (follow-up colonoscopies). ECP: European Cancer Prevention Organisation; SWOG: Southwest Oncology Group; n: Number of subjects with at least one adenoma detected during the follow-up evaluation; N: Number of subjects who underwent follow-up evaluation; RR: Risk ratio.