Risk of lymph node metastasis in mixed-type early gastric cancer determined by the extent of the poorly differentiated component

Figure 1 Pathology of mixed-type gastric carcinoma. A: Mixed-type gastric carcinoma showing moderately differentiated tubular adenocarcinoma, intestinal type (upper left and right) and poorly differentiated adenocarcinoma (lower left); B: High magnification view of poorly differentiated lesion (× 400); C: Mixed-type gastric carcinoma showing moderately differentiated tubular adenocarcinoma, intestinal type (right) and signet ring cell carcinoma (left); D: High magnification view of signet ring cell carcinoma lesion (× 400).

Figure 2 Receiver operating characteristics curve analysis of scores for predicting lymph node metastasis in mixed-type early gastric cancers yielded an area under the curve of 0. 687 (95%CI: 0.604-0.701, P < 0.0001) for the diffuse component, 0.610 (95%CI: 0.523-0.698, P = 0.023) for total size, 0.598 (95%CI: 0.505-0.691, P = 0.043) for the poorly differentiated component, and 0.556 (95%CI: 0.450-0.661, P = 0.249) for the signet ring cell component.