Intrahepatic distribution of hepatitis B virus antigens in patients with and without hepatocellular carcinoma

Figure 1 Images of pathology slides illustrating the classification system for intrahepatic hepatitis B surface antigen and hepatitis B core antigen. A: Diffuse distribution of HBsAg (× 2); B: Patchy distribution of HBcAg (× 2); C: Rare distribution of HBsAg (× 2); D: Cytoplasmic/nuclear pattern of HBcAg (× 20); E: Membranous pattern of HBsAg (× 20).

Figure 2 Diffuse hepatitis B core antigen distribution of mixed cytoplasmic, nuclear pattern in both tumor and adjacent non-tumor tissue (× 10). HCC: Hepatocellular carcinoma; HBcAg: Hepatitis B core antigen.

Figure 3 Diffuse hepatitis B core antigen distribution of mixed cytoplasmic, nuclear pattern in tumor tissue alone but not in adjacent non-tumor tissue (× 10). HCC: Hepatocellular carcinoma; HBcAg: Hepatitis B core antigen.