DNA methylation, microRNAs, and their crosstalk as potential biomarkers in hepatocellular carcinoma

doi:10.3748/wjg.v20.i24.7894

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2014; 20(24): 7894-7913
Published online Jun 28, 2014. doi: 10.3748/wjg.v20.i24.7894

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Figure 1 Mature microRNAs silenced by aberrant DNA methylation and their affected target genes and pathways that are important in the development and progression of hepatocellular carcinoma. PI3K: Phosphatidylinositol-3-kinase; MAPK: Mitogen-activated protein kinase; EGF: Epidermal growth factor; PDGF: Platelet-derived growth factor; HGF: Hepatocyte growth factor; mTOR: Mammalian target of rapamycin; VEGF: Vascular endothelial growth factor; MMP: Matrix metalloproteinase; APC: Activated protein C; CTNNB1: Beta-catenin.

Citation: Anwar SL, Lehmann U. DNA methylation, microRNAs, and their crosstalk as potential biomarkers in hepatocellular carcinoma. World J Gastroenterol 2014; 20(24): 7894-7913
URL: https://www.wjgnet.com/1007-9327/full/v20/i24/7894.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i24.7894