Sister Mary Joseph’s nodule as a first sign of pancreatic cancer

Figure 1 Appearance and pathology of umbilical tumor. A: A red nodule without ulcer appears in the umbilical region; B: Hematoxylin and eosin stain shows adenocarcinoma cell infiltration (×40).

Figure 2 Abdominal contrast-enhanced multi-detector computed tomography scan. A: A mass in the neck of pancreas (arrow) is shown in arterial phase; B: The mass in venous phase.

Figure 3 Positron emission tomography-computed tomography showed increased fludeoxyglucose uptake of tumors. A: Significant enhanced signal showing increased fludeoxyglucose (FDG) uptake at the site of pancreatic mass; B: Increased FDG uptake at the site of umbilical nodule.