KISS-1 inhibits the proliferation and invasion of gastric carcinoma cells

doi:10.3748/wjg.v18.i15.1827

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Apr 21, 2012 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 21, 2012; 18(15): 1827-1833
Published online Apr 21, 2012. doi: 10.3748/wjg.v18.i15.1827

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Figure 1 The expressions of KISS-1 and matrix metalloproteinase-9 mRNA and protein in BGC-823 cells. A: The expression level of KISS-1 mRNA was distinctly higher and the expression level of matrix metalloproteinase-9 (MMP-9) mRNA was distinctly lower in pcDNA3.1-KISS-1 group than that in pcDNA3.1 group (P < 0.05) and control group (P < 0.05); B: The expression level of KISS-1 protein was distinctly higher and the expression level of MMP-9 protein was distinctly lower in pcDNA3.1-KISS-1 group than that in pcDNA3.1 group (P < 0.05) and control group (P < 0.05). Lane 1: Control group; Lane 2: pcDNA3.1 group; Lane 3: pcDNA3.1-KISS-1group; MMP-9: Matrix metalloproteinase-9; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase.

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Figure 2 Suppression effects on invasion potency of BGC-823 by KISS-1 transfection. A: Control group; B: Group transfected with pcDNA3.1; C, D: Group transfected with pcDNA3.1-KISS-1.

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Figure 3 Inhibition effects on growth of BGC-823 by KISS-1 transfection in vivo. The tumor volume in pcDNA3.1-KISS-1 transfected group was significantly lower compared with pcDNA3.1 transfected group and control group.

Citation: Li N, Wang HX, Zhang J, Ye YP, He GY. KISS-1 inhibits the proliferation and invasion of gastric carcinoma cells. World J Gastroenterol 2012; 18(15): 1827-1833
URL: https://www.wjgnet.com/1007-9327/full/v18/i15/1827.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i15.1827