Growth inhibitory effect of 4-phenyl butyric acid on human gastric cancer cells is associated with cell cycle arrest

Figure 1 Effects of 4-phenyl butyric acid on the proliferation of gastric carcinoma MGC-803 cells (A) and SGC-7901 cells (B). Cells were incubated with 4-phenyl butyric acid at various concentrations for 24, 48, 72, and 96 h. The proliferation of cells was determined by the MTT assay. ^aP < 0.05, ^bP < 0.01 vs control. The relative inhibition rate was calculated as a percentage, as follows: (1-A_experiment/A_control) × 100%.

Figure 2 Effects of 4-phenyl butyric acid on cell cycle distribution of gastric carcinoma cells. The cell cycle was measured by propidium iodide staining and fluorescence-activated cell sorting analysis. ^aP < 0.05 vs control. MGC-803 cells (A) and SGC-7901 cells (B) were treated for 48 h; and MGC-803 cells (C) and SGC-7901 cells (D) were treated for 24 h.