CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma

doi:10.3748/wjg.v17.i19.2389

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May 21, 2011 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 21, 2011; 17(19): 2389-2396
Published online May 21, 2011. doi: 10.3748/wjg.v17.i19.2389

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Figure 1 Effect of stromal cell-derived factor-1 on proliferation of gastric cancer cells. Gastric cancer cells were grown in serum-free medium with or without the indicated doses of stromal cell-derived factor-1 (SDF-1). SDF-1 significantly increased the number of SGC-7901 and MGC-803 cells. Maximum effect was observed with 10 nmol/L SDF-1 (^aP < 0.05).

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Figure 2 Effect of stromal cell-derived factor-1 on migration of gastric cancer cells. Stromal cell-derived factor-1 (SDF-1) stimulated migration of cancer cells. Maximum effect was observed at 10 nmol/L of SDF-1 (^aP < 0.05).

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Figure 3 Effect of AMD3100 on stromal cell-derived factor-1-stimulated migration of gastric cancer cells. Gastric cancer cells were stimulated by stromal cell-derived factor-1 (SDF-1) at 10 nmol/L and various concentrations of AMD3100. Cell migration was decreased as the concentration of AMD3100 increased (^aP < 0.05).

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Figure 4 Expression of CXC chemokine receptor-4 in gastric carcinoma tissues and stromal cell-derived factor-1 in lymph nodes. A: CXC chemokine receptor-4 (CXCR4) protein was detected by immunohistochemistry in primary gastric carcinoma tissues; B: CXCR4 protein was not detected in normal mucous membrane; C: Stromal cell-derived factor-1 (SDF-1) protein was detected by immunohistochemistry in lymph nodes with gastric cancer cell metastasis; D: SDF-1 protein was not detected in normal lymph nodes (400 ×).

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Figure 5 mRNA expression of CXC chemokine receptor-4 in gastric cancer cells, tumors and normal mucous membranes and of stromal cell-derived factor-1 in lymph nodes. A: CXCR¹ : The expression of CXC chemokine receptor-4 (CXCR4) in gastric carcinoma tissues; CXCR²: Expression of CXCR4 in normal mucous membrane; B: Stromal cell-derived factor-1 (SDF-1): Expression of SDF-1 in lymph nodes; CXCR¹: Expression of CXCR4 in gastric cancer cell line SGC-7901; CXCR²: Expression of CXCR4 in gastric cancer cell line MGC-803; C: SDF-1¹: Expression of SDF-1 in lymph nodes with gastric cancer cell metastasis; SDF-1²: Expression of SDF-1.

Citation: Zhao BC, Wang ZJ, Mao WZ, Ma HC, Han JG, Zhao B, Xu HM. CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma. World J Gastroenterol 2011; 17(19): 2389-2396
URL: https://www.wjgnet.com/1007-9327/full/v17/i19/2389.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i19.2389