Alterations of tumor-related genes do not exactly match the histopathological grade in gastric adenocarcinomas

Figure 1 Gene expression levels of three different tissues. 1: Normal tissues; 2: Well differentiated gastric adenocarcinoma (GA); 3: Poorly differentiated GA. X-axis represents samples, and each unit represents a gene expression level of the corresponding sample. Y-axis represents genes, whose name marked at the right side of the figure. Green color indicates the low-expression level of corresponding gene, and red represents over-expression.

Figure 2 Distribution of gene expression levels. 1: APC; 2: Bcl10; 3: Beclin1; 4: BRCA1; 5: BRCA2; 6: FHIT; 7: KAI1; 8: NM23; 9: Ptch; 10: PTEN; 11: RB; 12: UVRAG; 13: TP53; 14: Cyclin D1; 15: C-myc.

Figure 3 Classification of two sample groups with a single gene. 1: Normal tissues; 2: Well differentiated GA; 3: Poorly differentiated GA. AUC: Area Under Curve.

Figure 4 Comparison of normal tissues and poorly differentiated GA (PDGA). X-axis represents the sequence of selected genes, and Y-axis represents the average and standard deviation of the AUC scores obtained in the ten 10-fold cross-validation (CV) with the corresponding gene groups.

Figure 5 Comparison of normal tissues and well differentiated GA (WDGA).

Figure 6 Comparison of WDGA and PDGA.