Interplay between inflammation, immune system and neuronal pathways: Effect on gastrointestinal motility

Figure 1 Hypothetical scheme of the complex interplay between, on the one hand residential macrophages (red), mast cells (blue), glial cells (green) and the recruitment of inflammatory cells (yellow), and on the other hand the activation of neuronal reflex pathways (black). Mediators involved in the different cell populations are marked in the same color as the cell type involved. NO: Nitric oxide; PG: Prostaglandins; SP: Substance P; CGRP: Calcitonin gene-related peptide; GABA: γ-aminobutyric acid; NGF: Neuropeptides, growth factors; PAF: Platelet-activating factor; TRPV: Transient receptor potential channel of the vanilloid subtype; nAChR: Nicotinic acetylcholine receptor.