Diagnostic sensitivity of imaging modalities for hepatocellular carcinoma smaller than 2 cm

Figure 1 Case No. 1: detection by gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging and computed tomography arterioportal angiography. Imaging and histological findings of the nodule in segment eight. A: Ultrasonography (US) reveals a 12 mm hyperechoic nodule (arrow); B: Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging reveals a defect (arrow) in the hepatobiliary phase; C, D: Computed tomography during arteriography reveals isodensity (C) and computed tomography during arterial portography (D) reveals a perfusion defect (arrow); E: The nodule is diagnosed as moderately-differentiated hepatocellular carcinoma by US-guided biopsy.

Figure 2 Case No. 2: detection by gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging. Imaging and histological findings of the nodule in segment six. A: Ultrasonography (US) reveals an 8 mm hyperechoic nodule (arrow); B: Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging reveals a defect (arrow) in the hepatobiliary phase; C: The nodule is diagnosed as well-differentiated hepatocellular carcinoma by US-guided biopsy, showing cellularity more than two-fold that of the non-tumorous area.