Functional magnetic resonance imaging in an animal model of pancreatic cancer

Figure 1 Histopathologic image obtained at necropsy. Border between viable VX2 tumor cells (black arrow) and healthy pancreatic tissue (white arrow) with irritated pancreatitis-like tissue at the tumor-pancreas interface (arrowhead). Note islet of Langerhans within healthy pancreatic tissue. Hematoxylin-eosin stain; original magnification × 25.

Figure 2 T2-weighted turbo spin echo magnetic resonance imaging showing pancreatic tumor (arrow) in axial view.

Figure 3 Single shot spin-echo planar diffusion weighted MRI (b = 500 s/mm²) showing pancreatic tumor (arrow) in axial view.

Figure 4 T1-weighted gradient-echo magnetic resonance [taken before (A) and after (B) TRIP imaging occurred]. Each image shows a VX2 tumor (solid arrows) located in the pancreas. Note the areas of increased perfusion to the viable tumor periphery in image B.

Figure 5 Signal intensity vs time curve for one pancreatic tumor, depicting higher signal intensity in the viable tumor periphery than in the necrotic tumor core.