Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease

Figure 1 The flowchart of study selection for the meta-analysis.

Figure 2 Association between thiopurine S-methyltransferase (TPMT) polymorphisms and all adverse drug reactions (ADRs) (A), bone marrow toxicity (B), hepatotoxicity (C) and pancreatitis (D). Total: Total number of patients within the ADRs or no ADRs group; Events: Number of patients with one or more TPMT alleles within the ADRs or no ADRs group. neg assoc: Favoured the no ADRs group; pos assoc: Favoured the ADRs group.

Figure 3 Funnel plot of included studies for this meta-analysis.