Usefulness of a scoring system in the interpretation of histology in neonatal cholestasis

Figure 1 Photomicrograph of liver biopsy (hematoxylin and eosin, original magnification × 200). A: A patient with biliary atresia obtained at 34 d of age (Patient NKC). A portal tract is shown here with no obvious bile ductular proliferation. There was hepatocytic degeneration and swelling. The original blinded histological diagnosis by the author was neonatal hepatitis; B: NKC obtained at 45 d of age. A portal tract is shown here with marked bile ductular proliferation, and bile plugs in bile ductules, typical of biliary atresia; C: A patient with biliary atresia (LQY) obtained at 78 d of life. There are multiple multinucleated giant cells, hepatocellular swelling and moderate lymphocytic infiltration. The original blinded histological diagnosis by the author was neonatal hepatitis.